3DBioFibR, a leading tissue engineering innovator, has announced the release of two new CollaFibR tissue engineering products, CollaFibR (pronounced micro-CollaFibR) and CollaFibR™ 3D scaffold. These off-the-shelf products, created using 3D BioFibR’s proprietary and new dry-spinning technology to create collagen fibres at commercial scales, offer significant advantages for tissue engineering and tissue culture applications and are now available for sale to the scientific and medical communities.
3D BioFibR manufactures high-value collagen fibres on a commercial scale for use in tissue engineering and medicine. The Company’s proprietary dry-spinning process yields fibres that are best-in-class in terms of strength, diameter, and quality, recreating collagen fibres’ natural appearance, structure, and function.
CollaFibR Tissue Engineering Products
CollaFibR™ is a bioink additive for use in laboratory 3D bioprinting of tissue and organ models. CollaFibR acts as a biological rebar in bioinks used to print living tissues, mimicking the body’s natural cellular scaffold. When combined with bioinks, CollaFibR increases the mechanical durability of printed tissues, allowing multiple cell types to be assembled layer by layer to create highly functional tissue and organ models.
“3D bioprinting is the future of regenerative medicine and it’s exciting to offer μCollaFibR to enhance the capabilities in 3D bioprinting. We all want to imagine a future where doctors could just print a kidney, using cells from the patient, instead of having to find a donor match. Our collagen fibers represent a significant improvement over existing scaffolds used in 3D bioprinting, moving the field closer to this reality.”– Kevin Sullivan, CEO of 3D BioFibR
In comparison to traditional 2D cultures, the CollaFibR™ scaffold for 3D cell culture allows researchers to study cellular reactions in a more physiologically relevant 3D environment. The CollaFibR scaffold has the advantage of using GMP type 1 collagen to create a consistent collagen fibre matrix that mimics the biomechanical and biochemical properties of natural cellular environments.
Sullivan added, “Our CollaFibR scaffold allows cells to grow and interact with the surrounding cellular scaffold in 3D, making it ideal for creating realistic tissue constructs for laboratory testing of new drugs and tissue models. Plus, our standard well plate dimensions are compatible with automated equipment for high throughput compound screening and advanced microscopy.”
Collagen is the primary structural element of the extracellular matrix in the human body. This matrix supports tissues by holding them together and providing mechanical durability. Collagen fibres also account for approximately 30% of the total protein content in the body. Although collagen has numerous biomedical applications, researchers and clinicians typically use digested collagen in its monomeric form (individual proteins). While monomeric collagen serves many important functions, scientists have been working for more than five decades to reassemble these individual proteins into fibres that closely resemble natural collagen fibres found in the body in terms of appearance, structure, and function.
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